An Efficacy and Safety Study of bb2121 in Subjects With Relapsed and Refractory Multiple Myeloma and in Subjects With High-Risk Multiple Myeloma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

248

Participants

Timeline

Start Date

December 13, 2018

Primary Completion Date

October 15, 2025

Study Completion Date

October 15, 2025

Conditions
Multiple Myeloma
Interventions
BIOLOGICAL

bb2121

bb2121 consists of autologous T lymphocytes transduced with an anti-BCMA CAR lentiviral vector to express a chimeric antigen receptor targeting the human B cell maturation antigen (anti-BCMA CAR)

DRUG

Lenalomide

Specified dose on specified days

DRUG

Talquetamab

Specified dose on specified days

Trial Locations (25)

10029

Mt Sinai Medical Center - NY, New York

10032

Columbia University Medical Center/New York-Presbyterian Hospital, New York

20246

Local Institution - 506, Hamburg

28204

Levine Cancer Institute, Charlotte

30322

Emory University School of Medicine, Atlanta

31008

Clinica Universidad de Navarra, Pamplona

33612

Moffitt Cancer Center, Tampa

37007

Local Institution - 704, Salamanca

37203

Tennessee Oncology PLLC, Nashville

40138

Local Institution - 603, Bologna

53226

Froedtert Hospital BMT Medical College of Wisconsin, Milwaukee

63110

Washington University, St Louis

75390

University Of Texas Southwestern Medical Center, Dallas

77030

MD Anderson Cancer Center The University of Texas, Houston

85259

Mayo Clinic in Arizona - Scottsdale, Scottsdale

86021

Local Institution - 404, Poitiers

94143

University Of California San Francisco Medical Center, San Francisco

97080

Local Institution - 505, Würzburg

98104

Swedish Cancer Inst, Seattle

02117

Massachusetts General Hospital, Boston

02215-5450

Dana Farber Cancer Institute, Boston

02215

Beth Israel Deaconess Medical Center, Boston

68198-7680

University Of Nebraska, Omaha

07601

John Theurer Cancer Center at Hackensack University Medical Center, Hackensack

SE5 9RS

Kings College Hospital NHS Foundation Trust, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY