Clinical Trial of SP-2577 (Seclidemstat) in Patients With Relapsed or Refractory Ewing or Ewing-related Sarcomas

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

June 4, 2018

Primary Completion Date

September 30, 2025

Study Completion Date

December 31, 2025

Conditions
Ewing SarcomaMyxoid LiposarcomaSarcoma,Soft TissueDesmoplastic Small Round Cell TumorExtraskeletal Myxoid ChondrosarcomaAngiomatoid Fibrous HistiocytomaClear Cell SarcomaPrimary Pulmonary Myxoid SarcomaMyoepithelial TumorSclerosing Epithelioid FibrosarcomaFibromyxoid Tumor
Interventions
DRUG

Seclidemstat

Twice daily administration of seclidemstat

DRUG

Cyclophosphamide

250 mg/m2/day on Days 1 thru 5 of a 21-day cycle

DRUG

Topotecan

0.75 mg/m2/day on Days 1 thru 5 of a 21-day cycle

Trial Locations (16)

10065

Memorial Sloan Kettering Cancer Center, New York

19111

Fox Chase Cancer Center, Philadelphia

32224

Mayo Clinic, Jacksonville

33612

H. Lee Moffitt Cancer Center and Research Institute, Tampa

33701

Johns Hopkins All Children's Hospital, St. Petersburg

43205

The Research Institute at Nationwide Children's Hospital, Columbus

44195

Cleveland Clinic Taussig Cancer Institute, Cleveland

55905

Mayo Clinic, Rochester

63110

Washington University, St Louis

77030

MD Anderson Cancer Center, Houston

Virginia Cancer Specialists, Fairfax

90027

Children's Hospital Los Angeles, Los Angeles

90403

Sarcoma Oncology Research Center, Santa Monica

97239

Oregon Health Sciences University, Portland

98109

University of Washington, Seattle

02215

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

National Pediatric Cancer Foundation

OTHER

lead

Salarius Pharmaceuticals, LLC

INDUSTRY