A Research Study of How NNC0174-0833 Taken With Semaglutide Works in People Who Are Overweight or Obese

PHASE1CompletedINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

July 25, 2018

Primary Completion Date

June 12, 2020

Study Completion Date

June 12, 2020

Conditions
ObesityOverweight
Interventions
DRUG

NNC0174-0833

Participants will receive increasing dose levels of 0.16 mg, 0.3 mg, 0.6 mg, 1.2 mg, 2.4 mg or 4.5 mg of NNC0174-0833 (subcutaneous \[s.c.\], in a lifted fold of the abdominal skin) injection once weekly starting with a very low dose and then escalated every 4 weeks to a slightly higher dose each time. Each participant will only be given one dose level.

DRUG

Semaglutide

Participants will receive 2.4 mg of semaglutide (s.c., in a lifted fold of the abdominal skin) injection once weekly starting with a very low dose and then escalated every 4 weeks to a slightly higher dose each time.

DRUG

Placebo (NNC0174-0833)

Participants will receive once weekly injections of NNC0174-0833 matched placebo.

Trial Locations (1)

66212

Novo Nordisk Investigational Site, Overland Park

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY