pTVG-HP and Nivolumab in Patients With Non-Metastatic PSA-Recurrent Prostate Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

September 10, 2018

Primary Completion Date

December 5, 2022

Study Completion Date

December 31, 2027

Conditions
Prostate Cancer
Interventions
BIOLOGICAL

pTVG-HP

Plasmid DNA vaccine encoding Prostatic Acid Phosphatase (PAP)

DRUG

Nivolumab

Nivolumab is a human programmed death receptor-1 (PD-1)-blocking antibody indicated for the treatment of patients with multiple different types of cancer.

DRUG

GM-CSF

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a growth factor that supports the survival, clonal expansion and differentiation of hematopoietic progenitor cells including dendritic antigen presenting cells.

Trial Locations (1)

53705

University of Wisconsin Carbone Cancer Center, Madison

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Madison Vaccines Inc. (MVI)

UNKNOWN

collaborator

AIQ Solutions

INDUSTRY

lead

University of Wisconsin, Madison

OTHER