Start Date
August 31, 2020
Primary Completion Date
December 31, 2022
Study Completion Date
May 31, 2024
Durvalumab
-Durvalumab infusion will start approximately 1 hour (maximum 2 hours) after the end of the tremelimumab infusion
Tremelimumab
-Tremelimumab will be administered first
TDS-IM v1.0 System
-Integrated electroporation device
Neoantigen DNA Vaccine
-At each vaccination time point, patients will receive two injections of the neoantigen DNA vaccine, one injection into each deltoid or lateralis.
Research blood draw
-Baseline, C2D1, C3D1, C5D1, C7D1, and C9D1
Collaborators (1)
MedImmune LLC
INDUSTRY
Washington University School of Medicine
OTHER