PolyImmune {Durvalumab (MEDI4736) and Tremelimumab} & Vaccine Orchestrated Treatment for Patients With Advanced/Metastatic Renal Cell Carcinoma

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

August 31, 2020

Primary Completion Date

December 31, 2022

Study Completion Date

May 31, 2024

Conditions
Renal Cell Carcinoma
Interventions
DRUG

Durvalumab

-Durvalumab infusion will start approximately 1 hour (maximum 2 hours) after the end of the tremelimumab infusion

DRUG

Tremelimumab

-Tremelimumab will be administered first

DEVICE

TDS-IM v1.0 System

-Integrated electroporation device

BIOLOGICAL

Neoantigen DNA Vaccine

-At each vaccination time point, patients will receive two injections of the neoantigen DNA vaccine, one injection into each deltoid or lateralis.

PROCEDURE

Research blood draw

-Baseline, C2D1, C3D1, C5D1, C7D1, and C9D1

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

MedImmune LLC

INDUSTRY

lead

Washington University School of Medicine

OTHER