Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003)

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

174

Participants

Timeline

Start Date

October 17, 2018

Primary Completion Date

January 16, 2026

Study Completion Date

January 16, 2026

Conditions
Hodgkin DiseaseLymphoma, Non-HodgkinLymphoma, B-Cell
Interventions
BIOLOGICAL

pembrolizumab

Administered as an IV infusion every 3 weeks (Q3W)

BIOLOGICAL

Favezelimab

Administered as an IV infusion Q3W

Trial Locations (25)

2139

Concord Repatriation & General Hospital ( Site 0203), Concord

3065

St Vincent s Hospital (Melbourne) Limited ( Site 0202), Fitzroy

3168

Monash Health ( Site 0201), Clayton

4102

Princess Alexandra Hospital ( Site 0204), Woollongabba

4103

Universitaetsklinikum Leipzig AOeR ( Site 0327), Leipzig

19111

Fox Chase Cancer Center ( Site 0019), Philadelphia

20089

Humanitas-U.O di Oncologia medica ed Ematologia ( Site 0352), Rozzano

40138

A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 0351), Bologna

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 0354), Meldola

50937

U. klinikum Koeln AOER ( Site 0326), Cologne

78705

Texas Oncology-Austin Midtown ( Site 8002), Austin

85234

Banner MD Anderson Cancer Center ( Site 0020), Gilbert

90095

Ronald Reagan UCLA Medical Center (Radiological Sciences) ( Site 0007), Los Angeles

91010

City of Hope ( Site 0001), Duarte

93940

Pacific Cancer Care ( Site 0006), Monterey

94143

University of California San Francisco ( Site 0023), San Francisco

3109601

Rambam Medical Center ( Site 0382), Haifa

5262001

Chaim Sheba Medical Center. ( Site 0380), Ramat Gan

6423906

Sourasky Medical Center ( Site 0381), Tel Aviv

9112001

Hadassah Ein Karem Jerusalem ( Site 0383), Jerusalem

02215

Dana Farber Cancer Institute ( Site 0002), Boston

V5Z 1L3

BC Cancer ( Site 0107), Vancouver

R3E 0V9

CancerCare Manitoba ( Site 0101), Winnipeg

M5G 2M9

Princess Margaret Cancer Centre ( Site 0100), Toronto

H3T 1E2

Jewish General Hospital ( Site 0105), Montreal

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03598608 - Study to Evaluate the Safety and Efficacy of a Combination of Favezelimab (MK-4280) and Pembrolizumab (MK-3475) in Participants With Hematologic Malignancies (MK-4280-003) | Biotech Hunter | Biotech Hunter