A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

October 29, 2018

Primary Completion Date

November 21, 2023

Study Completion Date

February 20, 2027

Conditions
Colitis, Ulcerative
Interventions
DRUG

Golimumab

Participants receive subcutaneous (SC) golimumab through Week 50, where doses will be based on body surface area. After the Week 54 evaluations, at the discretion of investigator, participants benefiting from continued SC golimumab will continue to receive SC golimumab in the extension until end of study.

DRUG

Infliximab

Participants will receive infliximab intravenous (IV) through Week 46. Doses will be based on body weight. After the Week 54 evaluations, participants receiving infliximab will be withdrawn from study participation and transition to local standard of care which may include continued commercially available infliximab at the discretion of their physician.

Trial Locations (58)

100

National Taiwan University Hospital, Taipei

112

Taipei Veterans General Hospital, Taipei

1020

Universitair Kinderziekenhuis Koningin Fabiola, Brussels

1090

UZ Brussel, Jette

1200

Cliniques Universitaires Saint Luc, Brussels

10032

Columbia University Medical Center, New York

19803

Nemours DuPont Hospital for Children, Wilmington

28009

Hosp. Infantil Univ. Nino Jesus, Madrid

28036

Hosp. Gral. Univ. Gregorio Maranon, Madrid

28041

Hosp. Univ. 12 de Octubre, Madrid

29011

Hosp Regional Univ de Malaga, Málaga

30342

Children's Center for Digestive Health Care, Atlanta

33000

Hopital Pellegrin CHU Bordeaux, Bordeaux

33305

Chang Gung Memorial Hospital- Linkou, Taoyuan

34137

IRCCS Materno Infantile Burlo Garofolo, Trieste

37922

GI For Kids, Knoxville

40133

Azienda USL di Bologna - Ospedale Maggiore, Bologna

41013

Hosp. Virgen Del Rocio, Seville

41404

Kyungpook National University Chilgok Hospital, Daegu

48902

Hosp. Univ. de Cruces, Barakaldo

50139

AOU Meyer, Florence

52621

Sheba Medical Center, Ramat Gan

55905

Mayo Clinic, Rochester

70300

Assaf Harofeh Medical Center, Rishon LeZiyyon

71013

Casa Sollievo Della Sofferenza IRCCS, San Giovanni Rotondo

75015

Hôpital Necker, Paris

75044

DHAT Research Institute, Garland

75207

Children's Medical Center of Dallas, Dallas

76104

Cook Childrens Medical Center, Fort Worth

80045

Children's Hospital Colorado and University of Colorado, Aurora

80124

Rocky Mountain Pediatric Gastroenterology, Lone Tree

91031

Shaare Zedek Medical Center, Jerusalem

94158

University of California San Francisco, San Francisco

98124

AOU Policlinico G.Martino, Messina

3109601

Rambam Medical Center, Haifa

4920235

Schneider Children's Medical Center, Petah Tikva

6997801

Sourasky Medical Center, Tel Aviv

06106

Connecticut Children's Medical Center, Hartford

89010-506

MK Blumenau Pesquisa Clínica, Blumenau

80250-060

Hospital Pequeno Principe, Curitiba

90035-074

Irmandade Santa Casa de Misericordia de Porto Alegre, Porto Alegre

01236030

BR Trials, São Paulo

00161

AOU Policlinico Umberto I, Roma

00165

IRCCS Ospedale Pediatrico Bambino Gesu, Roma

1105 AZ

Emma Children's Hospital Academic Medical Center, Amsterdam

8000 GK

Isala Kliniek, Zwolle

85 094

Szpital Uniwersytecki NR 1 IM Dr Antoniego Jurasza, Bydgoszcz

80 803

Szpital im. M. Kopernika, Gdansk

30 663

Uniwersytecki Szpital Dzieciecy w Krakowie, Krakow

10 561

Wojewodzki Specjalistyczny Szpital Dzieciecy im Prof Stanislawa Popowskiego, Olsztyn

35-302

Korczowski Bartosz Gabinet Lekarski, Rzeszów

00 635

Centrum Zdrowia Matki Dziecka i Mlodziezy, Warsaw

04-730

Szpital Pomnik Centrum Zdrowia Dziecka, Warsaw

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08950

Hosp. Sant Joan de Deu, Barcelona

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY