A Single-center Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of LCAR-L10D Cell Formulations Targeting CD19 and CD22 in Patients With CD19- and/or CD22-Positive Relapsed/Refractory B-cell Lymphoma

PHASE1TerminatedINTERVENTIONAL
Enrollment

1

Participants

Timeline

Start Date

May 30, 2019

Primary Completion Date

May 1, 2021

Study Completion Date

May 1, 2021

Conditions
Lymphoma, B-Cell
Interventions
DRUG

Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy

Patients will undergo leukapheresis to isolate peripheral blood mononuclear cells (PBMCs) for the production of CAR-T cells. After a pre-treatment lymphodepletion therapy, patients will receive the Dual Specificity CD19 and CD22 CAR-T Cell Immunotherapy by intravenous injection.

Trial Locations (1)

710000

Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an

Sponsors
All Listed Sponsors
collaborator

Nanjing Legend Biotech Co.

INDUSTRY

lead

Second Affiliated Hospital of Xi'an Jiaotong University

OTHER