413
Participants
Start Date
July 17, 2018
Primary Completion Date
December 30, 2026
Study Completion Date
June 30, 2028
Pazopanib
All patients will receive pazopanib at a starting dose of 800 mg by mouth (p.o.) daily on Days 1 to 28 of each treatment cycle. Patients should be instructed to take their once- daily oral dose of pazopanib at the same time each morning. Each dose of pazopanib should be taken with an 8 oz/240 mL glass of water either 1 hour before or 2 hours after a meal. Patients should be instructed to swallow the tablets whole and not chew them.
Abexinostat
The starting dose and schedule of abexinostat will be 80 mg p.o. BID on Days 1 to 4, 8 to 11, and 15 to 18 of every 28-day cycle, 2 doses 4 hours apart. Each dose of abexinostat should be taken with an 8 oz/240 mL glass of water at least half an hour before meals or more than 2 hours after a meal and must be 4 hours apart. Patients should be instructed to swallow the tablets whole and not chew them.
Placebo
The starting dose and schedule of abexinostat matching placebo will be 80 mg p.o. BID on Days 1 to 4, 8 to 11, and 15 to 18 of every 28-day cycle, 2 doses 4 hours apart. Each dose of placebo should be taken with an 8 oz/240 mL glass of water at least half an hour before meals or more than 2 hours after a meal and must be 4 hours apart. Patients should be instructed to swallow the tablets whole and not chew them.
WITHDRAWN
Fondazione del Piemonte per l'Oncologia_Istituto di Candiolo, IRCCS_ Oncologia Medica, Candiolo
COMPLETED
National Cancer Center - Center For Prostate Cancer, Goyang-si
WITHDRAWN
Northwell Health/Monter Cancer Center, Lake Success
COMPLETED
CHA Bundang Medical Center, CHA University, Seongnam-si
COMPLETED
Mainstreet Physicans Care, Rochester
COMPLETED
St. Luke's Hospital, Easton
WITHDRAWN
Istituto Europeo di Oncologia_Unità Oncologia Medica Urogenitale e Cervico Facciale, Milan
WITHDRAWN
Istituti Clinici Scientifici Maugeri Spa-SB_ UO Oncologia Medica, Pavia
WITHDRAWN
Hospital Universitario Fundación Jiménez Díaz, Madrid
COMPLETED
Hospital Universitario 12 de Octubre, Madrid
WITHDRAWN
Azienda Ospedaliero-Universitaria Maggiore della Carità Novara_SC Oncologia Medica, Novara
WITHDRAWN
H.U. Virgen de la Victoria, Málaga
COMPLETED
Norton Cancer Institute, Norton Healthcare Pavilion, Louisville
WITHDRAWN
Precision Cancer Research/Dayton Physicians Network - Treatment, Kettering
WITHDRAWN
IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) UO Oncologia Medica, Meldola (FC)
WITHDRAWN
Azienda Ospedaliero Universitaria Pisana_ UO Oncologia Medica Universitaria, Pisa
WITHDRAWN
GU Research Network/Urology Cancer Center, Omaha
COMPLETED
Nebraska Cancer Specialists, Omaha
COMPLETED
Ochsner Clinic Foundation, New Orleans
COMPLETED
HOPE Cancer Center of East Texas, Tyler
WITHDRAWN
Istituto Nazionale dei Tumori-Fondazione Pascale- SC Oncologia Medica, Napoli
WITHDRAWN
University Of UA Cancer Center(UACC)/DH-SJHMC, Phoenix
WITHDRAWN
UCSF Helen Diller Family Comphrensive Cancer Center - Hemato, San Francisco
WITHDRAWN
A.O. Cannizzaro_UOS Oncologia Medica, Catania
WITHDRAWN
University of California Davis Comprehensive Cancer Center, Sacramento
COMPLETED
Oregon Health and Science University, Portland
WITHDRAWN
Medical Oncology Associates, PS (dba Summit Cancer Centers), Spokane
RECRUITING
Beijing Cancer Hospital, Beijing
NOT_YET_RECRUITING
Zhongshan Hospital Affiliated to Fudan University, Shanghai
WITHDRAWN
Fondazione Policlinico Universitario A. Gemelli, U.O.C. Oncologia Medica, Roma
WITHDRAWN
Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny, Brzozów
WITHDRAWN
Szpitale Pomorskie Sp. z o.o. Oddział Onkologii i Radioterapii, Gdynia
COMPLETED
Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie Sp. z o.o. Oddział Onkologii Klinicznej z Pododdziałem Dziennym, Krakow
WITHDRAWN
Clinical Research Center Sp. z o.o., Medic-R Sp. K., Poznan
COMPLETED
Severance Hospital, Yonsei University Health System - Medical Oncology, Seoul
COMPLETED
Asan Medical Center - University of Ulsan College of Medicin, Seoul
WITHDRAWN
Samsung Medical Center - Hematology-Oncology, Seoul
WITHDRAWN
H.G.U. de Elche, Elche
Xynomic Pharmaceuticals, Inc.
INDUSTRY