INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

83

Participants

Timeline

Start Date

August 17, 2018

Primary Completion Date

November 21, 2022

Study Completion Date

November 21, 2022

Conditions
Unresectable or Metastatic Solid Tumors
Interventions
DRUG

Retifanlimab

"Part 1: INCMGA00012 at the protocol-defined starting dose administered intravenously every 4 weeks, with dose escalation to determine the maximum tolerated dose.~Part 2: INCMGA00012 at the recommended dose from Part 1."

DRUG

Epacadostat

"Part 1: Epacadostat at the protocol-defined starting dose administered orally twice daily, with dose escalation to determine the maximum tolerated dose.~Part 2: Epacadostat at the recommended dose from Part 1."

DRUG

INCB050465

Part 1: INCB050465 at the protocol-defined starting dose administered orally once daily, with dose escalation to determine the maximum tolerated dose. Part 2: INCB050465 at the recommended dose from Part 1.

Trial Locations (9)

14263

Roswell Park Cancer Institute, Buffalo

15232

Upmc Cancercenter, Pittsburgh

19104

Hospital of the University of Pennsylvania, Philadelphia

32610

University of Florida - Shands Cancer Center, Gainesville

60637

University of Chicago Medical Center, Chicago

78229

South Texas Accelerated Research Therapeutics, San Antonio

90025

The Angeles Clinic and Research Institute, Los Angeles

06510

Yale New Haven Hospital, New Haven

08901

Rutgers Cancer Institute of Nj, New Brunswick

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY

NCT03589651 - INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter