ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

82

Participants

Timeline

Start Date

August 22, 2018

Primary Completion Date

August 30, 2026

Study Completion Date

August 30, 2029

Conditions
Breast Cancer
Interventions
DRUG

T-DM1

T-DM1 is an antibody-drug conjugate; it is made up of an antibody (trastuzumab) linked to a cytotoxic drug, DM1 (chemotherapy). T-DM1 functions as a targeted cancer therapy because it targets HER2-positive breast cancer cells directly, limiting exposure of the rest of the body to chemotherapy.

Trial Locations (14)

10065

Memorial Sloan Kettering Cancer Center, New York

27599

University of North Carolina, Chapel Hill

27607

Rex Cancer Center, Raleigh

37203

Sarah Cannon Research Institute, Nashville

55905

Mayo Clinic, Rochester

91010

City of Hope Comprehensive Cancer Center, Duarte

06904

The Stamford Hospital, Stamford

02215

Dana Farber Cancer Institute, Boston

Massachusetts General Hospital, Boston

02135

Dana-Farber Cancer Institute at St. Elizabeth's Medical Center, Brighton

01757

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center, Milford

02190

Dana-Farber/Brigham and Women's Cancer Center in clinical affiliation with South Shore Hospital, South Weymouth

03053

Dana-Farber/New Hampshire Oncology-Hematology, Londonderry

02903

Lifespan Cancer Institute, Providence

All Listed Sponsors
collaborator

Susan G. Komen Breast Cancer Foundation

OTHER

collaborator

Gateway for Cancer Research

OTHER

lead

Dana-Farber Cancer Institute

OTHER

NCT03587740 - ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer | Biotech Hunter | Biotech Hunter