Does Cediranib With Paclitaxel, or Cediranib and Olaparib, Treat Advanced Endometrial Cancer Better Than Paclitaxel?

PHASE2UnknownINTERVENTIONAL
Enrollment

124

Participants

Timeline

Start Date

May 17, 2018

Primary Completion Date

January 31, 2023

Study Completion Date

June 30, 2023

Conditions
CarcinosarcomaEndometrial Neoplasms
Interventions
DRUG

Paclitaxel

80 mg/m2 on three days in a 28 day cycle (with 6 cycles)

DRUG

Cediranib

20 mg per day

DRUG

Olaparib

Olaparib tablets, 300 mg twice-daily

Trial Locations (15)

HA6 2RN

Mount Vernon Cancer Centre, Northwood

GU2 7 XX

Royal Surrey County Hospital, Guildford

BA1 3NG

Royal United Hospitals Bath NHS Foundation Trust, Bath

BS2 8ED

Bristol Haematology & Oncology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol

CF14 2TL

Velindre Cancer Centre, Velindre University NHS Trust, Cardiff

G12 0YN

Beatson West of Scotland Oncology Centre, Glasgow

BD20 6TD

Airedale NHS Foundation Trust, Keighley

LE1 5WW

Hope Clinical Trials Facility, Leicester Royal Infirmary, Leicester

L7 8YA

The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool

NW1 2BU

University College London Hospitals NHS Foundation Trust, London

SE1 9RT

Guys & St Thomas NHS Trust, London

Unknown

Royal Marsden Hospitals, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

NE7 7DN

Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne

OX3 7LE

The Churchill Hospital, Old Road, Headington, Oxford

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Cardiff University

OTHER

lead

University of Manchester

OTHER