Basal Cell Carcinomas Treated With Ablative Fractional Laser and Ingenol Mebutate

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 17, 2017

Primary Completion Date

May 18, 2018

Study Completion Date

May 18, 2018

Conditions
Carcinoma, Basal Cell
Interventions
DRUG

AFXl-assisted ingenol mebutate delivery

"Patients will receive ablative fractional laser (AFXl)-assisted ingenol mebutate (IM) as a treatment for their cutaneous basal cell carcinoma (BCC). Treatment areas consisting of tumors and a 5 mm margin will undergo AFXl exposure (CO2 laser) followed by IM 0.015% or 0.05% under occlusion for 2-3 days. .~local skin reactions are monitored at baseline (day1), day 3/4, day 8, day 15, day 29, day 90, and tumor response monitored at baseline, day 29, and day 90. An additional repeat AFXl-IM treatment on day 29 will be offered if tumors persist, based on clinical evaluation and imaging on day 30."

Trial Locations (1)

2400

Department of Dermtology, Bispebjerg University Hospital, Copenhagen, Denmark, Copenhagen

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

LEO Pharma

INDUSTRY

lead

Merete Haedersdal

OTHER

NCT03569345 - Basal Cell Carcinomas Treated With Ablative Fractional Laser and Ingenol Mebutate | Biotech Hunter | Biotech Hunter