Peri-Operative Immune Checkpoint Inhibition and Cryoablation in Women With Triple-negative Breast Cancer

Pembro will be administered 1-20 days before the cryoablation date per SOC and q3 weeks after surgery for 9 cycles per SOC.

US-guided core biopsy and cryoablation 7-10 days prior to surgery.

Standard-of-care definitive surgery.

ipilimumab 1mg/Kg IV is administered 1-5 days prior to cryoablation.

nivolumab 240mg IV flat dose is administered 1-5 days prior to cryoablation and 240mg IV every 2 weeks ± 3 days starting 3 (+/-1) weeks after surgery.