To Evaluate Safety, Tolerability, and Clinical Activity of the Antibody-drug Conjugate, GSK2857916 Administered in Combination With Lenalidomide Plus Dexamethasone (Arm A), or in Combination With Bortezomib Plus Dexamethasone (Arm B) in Participants With Relapsed/Refractory Multiple Myeloma (RRMM)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

153

Participants

Timeline

Start Date

September 20, 2018

Primary Completion Date

February 28, 2023

Study Completion Date

February 28, 2024

Conditions
Multiple Myeloma
Interventions
DRUG

Belantamab mafodotin

Selected doses of belantamab mafodotin will be administered as an infusion.

DRUG

Lenalidomide

Lenalidomide will be administered as 25 or 10 mg,orally, with belantamab mafodotin and dexamethasone.

DRUG

Dexamethasone

Dexamethasone will be administered as 20 or 40 mg, orally with belantamab mafodotin.

DRUG

Bortezomib

Bortezomib will be administered as 1.3 mg/m\^2, as SC or IV, with belantamab mafodotin and dexamethasone.

Trial Locations (26)

2500

GSK Investigational Site, Wollongong

3000

GSK Investigational Site, Melbourne

3004

GSK Investigational Site, Melbourne

3065

GSK Investigational Site, Fitzroy

5011

GSK Investigational Site, Woodville

6009

GSK Investigational Site, Nedlands

6150

GSK Investigational Site, Murdoch

8035

GSK Investigational Site, Barcelona

10022

GSK Investigational Site, New York

10467

GSK Investigational Site, The Bronx

28040

GSK Investigational Site, Madrid

28050

GSK Investigational Site, Madrid

29650

GSK Investigational Site, Greer

35294

GSK Investigational Site, Birmingham

37007

GSK Investigational Site, Salamanca

46202

GSK Investigational Site, Indianapolis

48910

GSK Investigational Site, Lansing

63110

GSK Investigational Site, St Louis

68803

GSK Investigational Site, Grand Island

75251

GSK Investigational Site, Dallas

85338

GSK Investigational Site, Goodyear

30322-4200

GSK Investigational Site, Atlanta

07601

GSK Investigational Site, Hackensack

H1T 2M4

GSK Investigational Site, Montreal

TR1 3LJ

GSK Investigational Site, Truro

W1T 7HA

GSK Investigational Site, London

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Iqvia Pty Ltd

INDUSTRY

lead

GlaxoSmithKline

INDUSTRY