Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQP

PHASE1CompletedINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

April 23, 2018

Primary Completion Date

April 19, 2019

Study Completion Date

April 19, 2019

Conditions
Malaria
Interventions
DRUG

480 mg Piperaquine phosphate

480 mg Piperaquine is a bis 4-aminoquinoline and was used mainly in China from the 1960's to the 1980's as an antimalarial monotherapy.

DRUG

640 mg Piperaquine phosphate

640 mg Piperaquine is a bis 4-aminoquinoline and was used mainly in China from the 1960's to the 1980's as an antimalarial monotherapy.

DRUG

200 mg OZ 439

200 mg OZ439 + α-tocopherol polyethylene glycol 1000 succinate (TPGS) granules for oral suspension

DRUG

400 mg OZ 439

400 mg OZ439 + α-tocopherol polyethylene glycol 1000 succinate (TPGS) granules for oral suspension

DRUG

800 mg OZ 439

800 mg OZ439 + α-tocopherol polyethylene glycol 1000 succinate (TPGS) granules for oral suspension

DRUG

960 mg PQP

960 mg Piperaquine is a bis 4-aminoquinoline and was used mainly in China from the 1960's to the 1980's as an antimalarial monotherapy.

DRUG

320 mg PQP

320 mg Piperaquine is a bis 4-aminoquinoline and was used mainly in China from the 1960's to the 1980's as an antimalarial monotherapy.

Trial Locations (1)

4006

Q-Pharm, Herston

All Listed Sponsors
collaborator

QIMR Berghofer Medical Research Institute

OTHER

collaborator

Clinical Network Services (CNS) Pty Ltd

INDUSTRY

collaborator

Q-Pharm Pty Limited

INDUSTRY

lead

Medicines for Malaria Venture

OTHER

NCT03542149 - Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQP | Biotech Hunter | Biotech Hunter