Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

800

Participants

Timeline

Start Date

January 3, 2019

Primary Completion Date

July 30, 2027

Study Completion Date

July 30, 2027

Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
DRUG

Early Highly Effective Therapies Group

Highly Effective MS Therapy group of medications

DRUG

Escalation Therapies Group

Escalation MS Therapy group of medications

Trial Locations (30)

14202

University of Buffalo, Buffalo

14642

University Rochester Medical Center, Rochester

22903

University of Virginia, Charlottesville

23284

Virginia Commonwealth University, Richmond

43214

Ohio Health, Columbus

44195

Cleveland Clinic, Cleveland

45267

University of Cincinnati, Cincinnati

53705

University of Wisconsin-Madison, Madison

55455

University of Minnesota, Minneapolis

55902

Mayo Clinic, Rochester

77030

Baylor College of Medicine, Houston, Houston

UTHealth-Houston, Houston

78712

UT-Austin, Austin

80045

University of Colorado-Anschutz Medical Campus, Aurora

89106

Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas

CV2 2DX

University Hospitals Coventry and Warwickshire, Coventry

LS1 3EX

The Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Leeds

LE1 5WW

University Hospitals Leicester, Leicester

W6 8RF

Imperial College Healthcare NHS Trust, Charing Cross Hospital, London

WC1N 3BG

University College London Hospitals NHS Foundation Trust, University College Hospital, London

M6 8HD

Salford Royal NHS Foundation Trust, Salford Hospital, Manchester

OX3 9DU

Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford

PL6 8DH

University Hospitals Plymouth NHS Trust, Derriford Hospital, Plymouth

S5 7AT

Sheffield Teaching Hospitals, Sheffield

ST4 6QG

University Hospitals of North Midlands, Stoke

EH16 4SA

Royal Infirmary of Edinburgh, Edinburgh

CF14 4XW

Cardiff and Vale University Local Health Board, University Hospital of Wales, Cardiff

NP19 0BH

Aneurin Bevan Local Health Board Headquarters, Royal Gwent Hospital, Newport

SA6 6NL

Swansea Bay University Local Health Board, Morriston Hospital, Swansea

NG7 2UH

Nottingham University Hospitals NHS Trust, Queens Medical Centre, Nottingham

All Listed Sponsors
collaborator

University of Nottingham

OTHER

lead

The Cleveland Clinic

OTHER