Safety and Immunogenicity Study of Venezuelan Equine Encephalomyelitis (VEE) Vaccine as Booster Vaccine in Adults

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

June 30, 2021

Primary Completion Date

December 31, 2023

Study Completion Date

December 31, 2024

Conditions
Venezuelan Equine Encephalomyelitis
Interventions
BIOLOGICAL

0.5 mL Inactivated, Dried, C-84, TSI-GSD 205, Lot 7, Run 1

"administered as dose(s) of 0.5 mL given subcutaneously in the upper outer aspect of the triceps area. Subjects who showed an initial immune response ≥ 1:20 to TC-83 and whose titer decreased over time or who rollover from a previous VEE C-84 protocol will receive a single 0.5 mL booster dose of C-84 vaccine.~Subjects who were initial non-responders (\< 1:20) to TC-83 will be given subcutaneous 0.5 mL injections on Days 0, 28-35, and 56-63"

Trial Locations (1)

21702

Special Immunizations Program/USAMRIID, Fort Deterick

All Listed Sponsors
lead

U.S. Army Medical Research and Development Command

FED