189
Participants
Start Date
May 14, 2018
Primary Completion Date
July 18, 2024
Study Completion Date
July 18, 2024
Maplirpacept (PF-07901801)
maplirpacept (PF-07901801) will be administered by intravenous infusion at ranging doses, as determined from sequential dosing cohorts.
Azacitidine
intravenous (IV) or subcutaneous (SC) daily for 7 days, repeated every 4 weeks
Venetoclax
orally daily for each day of each cycle (first 7 doses taken in clinic). The ramp-up and target dose of venetoclax will be adjusted per the package insert in subjects who are taking concomitant moderate or strong CYP3A4 inhibitors or posaconazole
Carfilzomib
Days 1, 8, and 15 of 28-day cycles; starting dose IV given on Cycle (C) 1 Day (D) 1, and if tolerated, then increased dose via IV given starting on C1D8 and subsequent doses thereafter.
Dexamethasone
starting dose via IV on Days 1, 8, 15, and increased dose via IV on 28-day cycles
Anti-CD20 Targeting agent
Days 1,8,15, and 22 of the first 28-day cycle and then on Day 1 of subsequent 21-day cycles. The anti-CD20 targeting agent will be administered for a total of eight doses, and then Cohort F1, F2 and F3: TTI-622 + isatuximab, carfilzomib and dexamethasone Cohort C1, C2 and C3: TTI-622 + Carfilzomib and Dexamethasone will be continued as single-agent therapy.
Isatuximab
"F1: IV dose C0D1, C0D8, C0D15 and C0D22 (lead in phase);weekly during Cycle 1; Cycle 2 and beyond will be administered on Days 1 and 15 (Q2W).~F2 and F3: IV dose C0D1 and C0D8 (lead in phase); C1D1, C1D8, C1D15 and C1D22; Cycle 2 and beyond will be administered on days 1 and 15 (Q2W). Carfilzomib: IV dose on days 1 and 2 of cycle 1; then increased IV dose on days 8, 9, 15, and 16 of cycle 1; cycle 2 and beyond: increased IV dose on days 1, 2, 8, 9, 15, and 16. Dexamethasone IV or PO on days 1, 2, 8, 9, 15, 16, 22, and 23 starting cycle 1."
Memorial Sloan Kettering Cancer Center - David H. Koch Center, New York
Memorial Sloan Kettering Cancer Center (Outpatient Center), New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center, The Bronx
Memorial Sloan Kettering Cancer Center at Westchester, Harrison
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy, Long Island City
Memorial Sloan Kettering Cancer Center at Nassau, Uniondale
Memorial Sloan Kettering Cancer Center at Commack, Commack
Roswell Park Cancer Institute, Buffalo
West Penn Hospital, Pittsburgh
Sidney Kimmel Cancer Center, Clinical Trials Organization, Philadelphia
Sidney Kimmel Cancer Center, Research Support Services, Philadelphia
Thomas Jefferson University - Clinical Research Institute, Philadelphia
Thomas Jefferson University Investigational Drug Services, Philadelphia
Thomas Jefferson University, Investigational Drug Service, Philadelphia
Thomas Jefferson University, Medical Oncology, Philadelphia
Thomas Jefferson University, Philadelphia
Christiana Care Health Services, Newark
Christiana Care Hematology Oncology - Helen F Graham Cancer Center, Newark
Medical Oncology Hematology Consultants, PA, Helen F. Graham Cancer Center, Newark
Christiana Care Health Services - Christiana Hospital, Newark
Georgetown University Medical Center, Washington D.C.
Novant Health Cancer Institute - Research Office, Winston-Salem
Novant Health Cancer Institute Hematology - Forsyth, Winston-Salem
Novant Health Forsyth Medical Center, Winston-Salem
Novant Health Cancer Institute - Research Office, Charlotte
Novant Health Cancer Institute Hematology - Charlotte, Charlotte
Novant Health Presbyterian Medical Center, Charlotte
Prisma Health, Institute for Translational Oncology Research, Clinical Research Unit, Greenville
Prisma Health-Upstate Cancer Institute, Greenville
Blood and Marrow Transplant Group of Georgia, Atlanta
Northside Hospital, Atlanta
Tampa General Hospital Cancer Institute, Tampa
Tampa General Hospital, Tampa
University of TN Medical Center, Knoxville
Norton Cancer Institute, St Matthews Campus, Louisville
Norton Cancer Institute, St. Matthews Campus, Attn. Becky Champion, PharmD, Louisville
Norton Diagnostic Center-Dupont (PET Scans), Louisville
Norton Women & Children's Hospital, Louisville
Gabrail Cancer Center Research, Canton
Indiana Blood & Marrow Transplantation, Indianapolis
Indiana Blood and Marrow Transplantation-Administrative Offices, Indianapolis
Indiana Blood and Marrow Transplantation-Clinic, Indianapolis
University of Michigan Hospitals, Ann Arbor
University of Michigan, Ann Arbor
Barbara Ann Karmanos Cancer Institute, Detroit
Karmanos Cancer Institute Weisberg Cancer Treatment Center, Farmington Hills
Oncology Consultants P.A., Houston
The University of Texas MD Anderson Cancer Center, Houston
Colorado Blood Cancer Institute, Denver
HealthONE Presbyterian/St. Luke's Medical Center, Denver
Keck Hospital of USC, Los Angeles
LAC+USC Medical Center, Los Angeles
USC/Norris Comprehensive Cancer Center, Los Angeles
Keck Hospital of USC Pasadena, Pasadena
Swedish Cancer Institute, Seattle
Swedish Medical Center, Seattle
Memorial Sloan Kettering Cancer Center at Basking Ridge, Basking Ridge
Summit Medical Group Cancer Center, Florham Park
Memorial Sloan Kettering Cancer Center at Monmouth, Middletown
Memorial Sloan Kettering Bergen, Montvale
Memorial Sloan Kettering Cancer Center at Montvale, Montvale
Lead Sponsor
Pfizer
INDUSTRY