A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

401

Participants

Timeline

Start Date

April 24, 2018

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2025

Conditions
Selected Advanced Solid Tumors
Interventions
BIOLOGICAL

MEDI5752

Subjects will remain on treatment until unacceptable toxicity, documentation of progressive disease, or development of other reason for treatment discontinuation.

DRUG

Pemetrexed

Subjects will remain on treatment until unacceptable toxicity, documentation of progressive disease, or development of other reason for treatment discontinuation

DRUG

Carboplatin

Subjects will remain on treatment until unacceptable toxicity, documentation of progressive disease, or development of other reason for treatment discontinuation

BIOLOGICAL

Pembrolizumab

Subjects will remain on treatment until unacceptable toxicity, documentation of progressive disease, or development of other reason for treatment discontinuation

DRUG

Paclitaxel or Nab-Paclitaxel

Subjects will remain on treatment until unacceptable toxicity, documentation of progressive disease, or development of other reason for treatment discontinuation

Trial Locations (40)

168

Research Site, Roma

2031

Research Site, Randwick

3000

Research Site, Melbourne

3004

Research Site, Melbourne

10048

Research Site, Taipei

10065

Research Site, New York

13620

Research Site, Gyeonggi-do

15006

Research Site, A Coruña

21565

Research Site, Incheon

22031

Research Site, Fairfax

27599

Research Site, Chapel Hill

28222

Research Site, Majadahonda

28644

Research Site, Cheongju-si

29010

Research Site, Málaga

31008

Research Site, Pamplona

33075

Research Site, Bordeaux

37203

Research Site, Nashville

37404

Research Site, Chattanooga

40705

Research Site, Taichung

46010

Research Site, Valencia

47014

Research Site, Meldola

48121

Research Site, Ravenna

48202

Research Site, Detroit

69373

Research Site, Lyon

70403

Research Site, Tainan City

80131

Research Site, Napoli

94805

Research Site, Villejuif

02903

Research Site, Providence

1066 CX

Research Site, Amsterdam

1649-035

Research Site, Lisbon

4200-072

Research Site, Porto

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

08003

Research Site, Barcelona

08028

Research Site, Barcelona

08035

Research Site, Barcelona

08041

Research Site, Barcelona

08916

Research Site, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

MedImmune LLC

INDUSTRY

NCT03530397 - A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter