4
Participants
Start Date
November 8, 2018
Primary Completion Date
November 13, 2020
Study Completion Date
November 13, 2020
Nivolumab induction
2 doses Nivolumab 240mg IV
Cisplatin
40 mg/m2 of cisplatin: Dosing on Days: 1, 8, 15, 22, 29, 36 beginning on day 1 of radiation therapy.
Radiation
"Total dose of 45 Gy in 25 fractions at 180 cGy/fx~Whole pelvic or extended field"
Nivolumab with chemoradiation
Nivolumab 240mg IV every 14 days (+/- 3 days) for 3 doses, administered concomitantly during chemoradiation and beginning day 1 of Radiation.
Nivolumab maintenance
Nivolumab 480 mg IV every 4 weeks for 2 years
Rhode Island Hospital, Providence
Women and Infants Hospital, Providence
Lead Sponsor
Collaborators (1)
Rhode Island Hospital
OTHER
The Miriam Hospital
OTHER
Women and Infants Hospital of Rhode Island
OTHER
Bristol-Myers Squibb
INDUSTRY
Brown University
OTHER