The DETOURS Trial: De-escalating Empiric Treatment: Opting Out of Rx for Selected Patients With Suspected Sepsis - Opt-Out Protocol Trial

NACompletedINTERVENTIONAL
Enrollment

762

Participants

Timeline

Start Date

September 12, 2018

Primary Completion Date

August 3, 2020

Study Completion Date

August 10, 2020

Conditions
Antibiotic Stewardship
Interventions
OTHER

Opt-Out Protocol

Should an eligible patient pass the safety screen and be randomized to the intervention arm of the trial, the designated pharmacist will approach the patient's primary provider in charge of antibiotic decision-making The pharmacist will inform the provider the patient's antibiotics can be de-escalated unless the provider opts out.

Trial Locations (10)

19104

Hospital of the University of Pennsylvania, Philadelphia

Pennsylvania Presbyterian Hospital, Philadelphia

27710

Duke University, Durham

27893

Wilson Medical Center, Wilson

28358

Southeastern Regional Medical Center, Lumberton

28677

Iredell Health System, Statesville

30214

Piedmont Fayette Hospital, Fayetteville

30265

Piedmont Newnan Hospital, Newnan

30309

Piedmont Atlanta Hospital, Atlanta

02115

Harvard Brigham and Women's Hospital, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Duke University

OTHER