Clinical Study of Combined Radical Operation With Postoperative Adjuvant Chemotherapy and Prophylactic Cranial Irradiation in pT1-2N0M0 Stage of Small Cell Lung Cancer

NARecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

August 31, 2018

Primary Completion Date

March 31, 2021

Study Completion Date

March 31, 2026

Conditions
Small-cell Lung Cancer
Interventions
PROCEDURE

prophylactic cranial irradiation (PCI)

Patients in the control group are enrolled in the follow-up, and the patients in research group will receive prophylactic cranial irradiation (PCI) by 25 gy/10 fx.

PROCEDURE

lobectomy + mediastinal lymph node dissection or systematic lymph node sampling

lobectomy + mediastinal lymph node dissection or systematic lymph node sampling

DRUG

postoperative adjuvant chemotherapy

If the postoperatively pathological examination of the patient is confirmed to be in pT1-2N0 stage, a single postoperative adjuvant chemotherapy (combining etoposide with cisplatin) is recommended. If patients are difficult to tolerate the side effects of cisplatin, we can replace cisplatin by carboplatin in the adjuvant chemotherapy scheme.

Trial Locations (1)

200000

RECRUITING

Shanghai Pulmonary Hospital, Shanghai

All Listed Sponsors
lead

Peng Zhang

OTHER