95
Participants
Start Date
August 29, 2018
Primary Completion Date
July 1, 2025
Study Completion Date
July 1, 2026
NGS-MRD
Next generation sequencing minimal residual disease (NGS-MRD) is a test that has increased sensitivity over multichannel flow cytometry to better identify risk of key outcomes after HCT. Patients that have a pre-HCT negative NGS-MRD results may be eligible to proceed to the treatment arm of the study that uses a non-TBI conditioning regimen.
Myeloablative allogeneic HCT with a non-TBI conditioning regimen
"Myeloablative study regimen will consist of busulfan, fludarabine and thiotepa.~day -7: Fludarabine and Busulfan day -6: Fludarabine and Busulfan day -5: Fludarabine and Busulfan day -4: Fludarabine and Busulfan day -3: Fludarabine day -2: Thiotepa day -1: Rest Day 0: Transplant"
RECRUITING
Roswell Park Cancer Institute, Buffalo
RECRUITING
Alfred I. duPont Hospital for Children - Nemours Deleware, Wilmington
RECRUITING
Atrium Health - Levine Cancer Center, Charlotte
RECRUITING
Children's Healthcare of Atlanta, Atlanta
RECRUITING
University of Florida, Gainesville
RECRUITING
Nicklaus Children's Hospital, Miami
RECRUITING
Johns Hopkins All Children's Hospital, St. Petersburg
RECRUITING
Children's of Alabama/University of Alabama in Birmingham(UAB), Birmingham
RECRUITING
Riley Hospital for Children - Indiana University, Indianapolis
RECRUITING
Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids
RECRUITING
Children's Mercy Hospital, Kansas City
RECRUITING
The University of Texas M. D. Anderson Cancer Center, Houston
RECRUITING
Methodist Healthcare System, San Antonio
RECRUITING
Children's Hospital Colorado, Aurora
RECRUITING
Phoenix Children's Hospital, Phoenix
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
UCLA Mattel Children's Hospital, Los Angeles
RECRUITING
City of Hope, Duarte
RECRUITING
UCSF, San Francisco
RECRUITING
UCSF Benioff Children's Hospital Oakland, Oakland
RECRUITING
Yale University School of Medicine, New Haven
RECRUITING
Floating Hospital for Children at Tufts Medical Center, Boston
RECRUITING
Dana Faber Cancer Institute/ Boston Children's Hospital, Boston
RECRUITING
Hackensack University Medical Center, Hackensack
Pediatric Transplantation & Cellular Therapy Consortium
OTHER