Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

May 2, 2018

Primary Completion Date

December 31, 2020

Study Completion Date

January 8, 2025

Conditions
Carcinoma, Squamous Cell of Head and NeckCarcinoma, Non-Small-Cell LungSmall Cell Lung Carcinoma
Interventions
DRUG

Durvalumab

IV (intravenous)

DRUG

Tremelimumab

IV

DRUG

Cisplatin (dose level 4)

IV

DRUG

Cisplatin (dose level 3)

IV

DRUG

Carboplatin (dose level 1)

IV

DRUG

Carboplatin (dose level 2)

IV

DRUG

Etoposide (dose level 1)

IV

DRUG

Etoposide (dose level 2)

IV

DRUG

Paclitaxel

IV

DRUG

Pemetrexed

IV

RADIATION

External beam radiation (dose level 1)

radiation therapy

RADIATION

External beam radiation (dose level 2)

radiation therapy

RADIATION

External beam radiation (hyperfractionated)

radiation therapy

DRUG

Cisplatin (dose level 1)

IV

DRUG

Cisplatin (dose level 2)

IV

RADIATION

External beam radiation (standard)

radiation therapy

Trial Locations (16)

112

Research Site, Taipei

333

Research Site, Taoyuan

10002

Research Site, Taipei

28007

Research Site, Madrid

29010

Research Site, Málaga

40705

Research Site, Taichung

77090

Research Site, Houston

80045

Research Site, Aurora

85719

Research Site, Tucson

135-8550

Research Site, Kōtoku

411-8777

Research Site, Sunto-gun

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

08916

Research Site, Badalona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY