NCT03507257 - Longitudinal Early-onset Alzheimer's Disease Study Protocol | Biotech Hunter

Enrollment

850

Participants

Timeline

Start Date

April 30, 2018

Primary Completion Date

May 31, 2026

Study Completion Date

May 31, 2026

Conditions

Early Onset Alzheimer DiseaseAlzheimer DiseaseMild Cognitive Impairment

Interventions

DRUG

Flortaucipir

All participants will receive a single bolus intravenous injection of approximately 10 mCi (+/- 10%, 20μg mass dose) of flortaucipir (18F-AV-1451). At approximately 75-minutes post dose, scanning will begin. An approximately 30-minute image acquisition scan will be performed.

DRUG

Florbetaben

All participants will receive a single bolus intravenous injection of approximately 8 mCi +/- .8mCi of florbetaben (AV-45). At approximately 90-minutes (+/- 10 minutes) post dose, scanning will begin. An approximately 20-minute image acquisition scan will be performed.

DRUG

Fluorodeoxyglucose

All participants will receive a single bolus intravenous injection of approximately 5 mCi (+/- 10%, 0.5 mCi) of fluorodeoxyglucose. At approximately 30 minutes post dose, scanning will begin. An approximately 30-minute image acquisition scan will be performed.

Trial Locations (23)

8041

NOT_YET_RECRUITING

Hospital de la Santa Creu i Sant Pau, Barcelona

10032

RECRUITING

Columbia University, New York

19104

RECRUITING

University of Pennsylvania, Philadelphia

20057

RECRUITING

Georgetown University, Washington D.C.

21218

RECRUITING

Johns Hopkins University, Baltimore

30322

RECRUITING

Emory University, Atlanta

32224

RECRUITING

Mayo Clinic, Jacksonville, Jacksonville

33140

RECRUITING

Wien Center, Miami Beach

47405

RECRUITING

Indiana University, Indianapolis

55905

RECRUITING

Mayo Clinic, Rochester, Rochester

60611

RECRUITING

Northwestern University, Chicago

63130

RECRUITING

Washington University, St. Louis, St Louis

77030

RECRUITING

Houston Methodist Hospital, Houston

85351

RECRUITING

Banner Sun Health Research Institute, Sun City

90095

RECRUITING

University of California, Los Angeles, Los Angeles

94121

RECRUITING

University of California, San Francisco, San Francisco

94304

RECRUITING

Stanford University, Palo Alto

02114

RECRUITING

Massachusetts General Hospital, Boston

02906

RECRUITING

Butler Hospital, Providence

C1428 CABA

NOT_YET_RECRUITING

Fleni, Buenos Aires

1081 HZ

NOT_YET_RECRUITING

Amsterdam UMC, Amsterdam

214 28

NOT_YET_RECRUITING

Lund University, Malmo

WC1N 3BG

NOT_YET_RECRUITING

University College London, London