NCT03505853View on ClinicalTrials.gov

A Study to Investigate the Interaction Between Givosiran and a 5-probe Drug Cocktail in Patients With Acute Intermittent Porphyria (AIP)

PHASE1CompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

April 26, 2018

Primary Completion Date

November 16, 2018

Study Completion Date

January 10, 2019

Conditions
Acute Intermittent Porphyria (AIP)Acute Hepatic Porphyria (AHP)Porphyria, Acute IntermittentAcute Porphyria
Interventions
DRUG

Givosiran

single dose of givosiran by subcutaneous (sc) injection

DRUG

5-probe cocktail

includes midazolam, caffeine, losartan, omeprazole, and dextromethorphan

Trial Locations (1)

Unknown

Clinical Trial Site, Stockholm

Sponsors
All Listed Sponsors
lead

Alnylam Pharmaceuticals

INDUSTRY