Coronary Atherosclerosis T1-Weighted Characterization (CATCH)

MRI with/without administration of a contrast agent and beta-blocker based upon the stage of method development, if no contraindications are present.

The intravenous gadolinium based contrast agent to be used in this study is Gadavist (up to 0.2 mmol/kg).

Based upon the focus of the study at the time of the scan, a beta- blocker (metoprolol), in pill form based upon blood pressure and heart rate, may be administered to some subjects to improve the heart's ability to relax and slow the heart rate. The slower heart rate may improve image quality and lessen motion artifact.