More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

April 3, 2019

Primary Completion Date

February 18, 2023

Study Completion Date

April 22, 2025

Conditions
HIV Infections
Interventions
DRUG

Oral Cabotegravir (CAB)

30 mg tablets administered orally

DRUG

Oral Rilpivirine (RPV)

25 mg tablets administered orally

DRUG

Long-Acting Injectable Cabotegravir (CAB LA)

Administered by intramuscular (IM) injection

DRUG

Long-Acting Injectable Rilpivirine (RPV LA)

Administered by intramuscular (IM) injection

DRUG

Combination Antiretroviral Therapy (cART)

Participants will continue their pre-study cART regimen. The antiretroviral drugs in participants' cART regimens were not provided through the study.

Trial Locations (19)

1862

Soweto CRS, Site 8052, Soweto

2001

Wits RHI Shandukani Research Centre CRS, Johannesburg

4066

Umlazi CRS, Umlazi

7505

Famcru Crs, Tygerberg Hills

10700

Siriraj Hospital Mahidol University, Bangkok

21287

Johns Hopkins Univ. Baltimore NICHD CRS, Baltimore

30322

Emory University School of Medicine NICHD CRS, Atlanta

33136

Pediatric Perinatal HIV NICHD CRS, Site 5127, Miami

50100

Chiangrai Prachanukroh Hospital NICHD CRS, Chiang Mai

50200

Chiang Mai University HIV Treatment (CMU HIV Treatment) CRS, Chiang Mai

72052

Baylor-Uganda CRS, Kampala

77030

Baylor College of Medicine/ Texas Children's Hospital NICHD CRS, Houston

80045

Univ. of Colorado Denver NICHD CRS, Aurora

90089

Usc La Nichd Crs, Los Angeles

60614-3393

Lurie Children's Hospital of Chicago (LCH) CRS, Chicago

38105-3678

St. Jude Children's Research Hospital CRS, Memphis

Unknown

Gaborone CRS, Gaborone

Molepolole CRS, Site 12702, Molepolole

MU-JHU Care Limited CRS, Kampala

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ViiV Healthcare

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH