The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products

Participants will wear the nicotine patch daily while switching from cigarette use to use of e-cigarettes for eight weeks.

Participants will wear the placebo patch daily while switching from cigarette use to use of e-cigarettes for eight weeks.

Participants will use e-cigarettes containing nicotine while switching from cigarette use to use of e-cigarettes for eight weeks.

Participants will use e-cigarettes not containing nicotine while switching from cigarette use to use of e-cigarettes for eight weeks.