A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

PHASE4CompletedINTERVENTIONAL
Enrollment

732

Participants

Timeline

Start Date

June 25, 2018

Primary Completion Date

March 18, 2019

Study Completion Date

March 18, 2019

Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
DRUG

budesonide/formoterol

Subjects will be administered two inhalations of budesonide/formoterol via MDI twice daily

DRUG

albuterol/salbutamol

Subjects will be provided short-acting albuterol/salbutamol as-rescue medication to be used on an as-needed basis throughout the study.

DRUG

FF/UMEC/VI

Subjects will receive FF/UMEC/VI 100/62.5/25 mcg via ELLIPTA once daily in the morning

DRUG

Placebo to match budesonide/formoterol

Subjects will be administered two inhalations of matching placebo twice daily via MDI

DRUG

tiotropium

Subjects will receive tiotropium (18 mcg) once daily in the morning via HandiHaler device

DRUG

Placebo to match FF/UMEC/VI

Matching placebo to FF/UMEC/VI will be administered via ELLIPTA once daily in the morning.

DRUG

placebo to match tiotropium

Subjects will receive tiotropium matching placebo via Handihaler once daily in the morning

DEVICE

ELLIPTA

Subjects will receive FF/UMEC/VI 100/62.5/25 mcg and matching placebo via ELLIPTA in the treatment period. Budesonide/formoterol plus tiotropium once daily plus placebo will be administered via ELLIPTA during the run-in period.

DEVICE

MDI

Subjects will receive budesonide/formoterol and placebo to match budesonide/formoterol via MDI in the treatment period.

DEVICE

HandiHaler

Subjects will be administered tiotropium (18 mcg) or placebo to match tiotropium via HandiHaler during the treatment period.

Trial Locations (57)

10119

GSK Investigational Site, Berlin

12159

GSK Investigational Site, Berlin

14467

GSK Investigational Site, Potsdam

15025

GSK Investigational Site, Jefferson Hills

21502

GSK Investigational Site, Geesthacht

23225

GSK Investigational Site, Richmond

23552

GSK Investigational Site, Lübeck

28117

GSK Investigational Site, Mooresville

28207

GSK Investigational Site, Charlotte

29303

GSK Investigational Site, Spartanburg

29325

GSK Investigational Site, Clinton

29379

GSK Investigational Site, Union

29464

GSK Investigational Site, Mt. Pleasant

29615

GSK Investigational Site, Greenville

30019

GSK Investigational Site, Dacula

30096

GSK Investigational Site, Duluth

31224

GSK Investigational Site, Peine

31326

GSK Investigational Site, Rincon

32750

GSK Investigational Site, Longwood

32789

GSK Investigational Site, Winter Park

33016

GSK Investigational Site, Hialeah

33125

GSK Investigational Site, Miami

33126

GSK Investigational Site, Miami

33133

GSK Investigational Site, Miami

33155

GSK Investigational Site, Miami

33165

GSK Investigational Site, Miami

33175

GSK Investigational Site, Kendall

33765

GSK Investigational Site, Clearwater

33870

GSK Investigational Site, Sebring

34747

GSK Investigational Site, Celebration

34748

GSK Investigational Site, Leesburg

36608

GSK Investigational Site, Mobile

37388

GSK Investigational Site, Tullahoma

43123

GSK Investigational Site, Grove City

44263

GSK Investigational Site, Dortmund

45231

GSK Investigational Site, Cincinnati

47714

GSK Investigational Site, Evansville

48307

GSK Investigational Site, Rochester

48336

GSK Investigational Site, Farmington Hills

48431

GSK Investigational Site, Rheine

60201

GSK Investigational Site, Evanston

63141

GSK Investigational Site, St Louis

69002

GSK Investigational Site, Břeclav

75069

GSK Investigational Site, McKinney

78006

GSK Investigational Site, Boerne

78229

GSK Investigational Site, San Antonio

92120

GSK Investigational Site, San Diego

92683

GSK Investigational Site, Westminster

93301

GSK Investigational Site, Bakersfield

95823

GSK Investigational Site, Sacramento

98405

GSK Investigational Site, Tacoma

748 01

GSK Investigational Site, Hlučín

360 17

GSK Investigational Site, Karlovy Vary

473 01

GSK Investigational Site, Nový Bor

407 47

GSK Investigational Site, Varnsdorf

03050

GSK Investigational Site, Cottbus

04207

GSK Investigational Site, Leipzig

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY

NCT03478696 - A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC /VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD) | Biotech Hunter | Biotech Hunter