A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD)

PHASE4CompletedINTERVENTIONAL
Enrollment

729

Participants

Timeline

Start Date

June 25, 2018

Primary Completion Date

March 14, 2019

Study Completion Date

March 14, 2019

Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
DRUG

budesonide/formoterol

Subjects will be administered two inhalations of budesonide/formoterol via MDI twice daily

DRUG

albuterol/salbutamol

Subjects will be provided short-acting albuterol/salbutamol as-rescue medication to be used on an as-needed basis throughout the study.

DRUG

FF/UMEC/VI

Subjects will receive FF/UMEC/VI 100/62.5/25 mcg via ELLIPTA once daily in the morning

DRUG

Placebo to match budesonide/formoterol

Subjects will be administered two inhalations of matching placebo twice daily via MDI

DRUG

tiotropium

Subjects will receive tiotropium (18 mcg) once daily in the morning via HandiHaler device

DRUG

Placebo to match FF/UMEC/VI

Matching placebo to FF/UMEC/VI will be administered via ELLIPTA once daily in the morning.

DRUG

placebo to match tiotropium

Subjects will receive tiotropium matching placebo via Handihaler once daily in the morning

DEVICE

ELLIPTA

Subjects will receive FF/UMEC/VI 100/62.5/25 mcg and matching placebo via ELLIPTA in the treatment period. Budesonide/formoterol plus tiotropium once daily plus placebo will be administered via ELLIPTA during the run-in period.

DEVICE

MDI

Subjects will receive budesonide/formoterol and placebo to match budesonide/formoterol via MDI in the treatment period.

DEVICE

HandiHaler

Subjects will be administered tiotropium (18 mcg) or placebo to match tiotropium via HandiHaler during the treatment period.

Trial Locations (57)

10455

GSK Investigational Site, The Bronx

12157

GSK Investigational Site, Berlin

15562

GSK Investigational Site, Rüdersdorf

20354

GSK Investigational Site, Hamburg

22927

GSK Investigational Site, Großhansdorf

27607

GSK Investigational Site, Raleigh

28150

GSK Investigational Site, Shelby

28801

GSK Investigational Site, Asheville

29204

GSK Investigational Site, Columbia

29303

GSK Investigational Site, Spartanburg

29464

GSK Investigational Site, Mt. Pleasant

29615

GSK Investigational Site, Greenville

29621

GSK Investigational Site, Anderson

29640

GSK Investigational Site, Easley

29707

GSK Investigational Site, Fort Mill

29720

GSK Investigational Site, Lancaster

29732

GSK Investigational Site, Rock Hill

30071

GSK Investigational Site, Peachtree Corners

30159

GSK Investigational Site, Hanover

30173

GSK Investigational Site, Hanover

32127

GSK Investigational Site, Port Orange

32132

GSK Investigational Site, Edgewater

32713

GSK Investigational Site, DeBary

33135

GSK Investigational Site, Miami

33144

GSK Investigational Site, Miami

33165

GSK Investigational Site, Miami

33186

GSK Investigational Site, Miami

33756

GSK Investigational Site, Clearwater

33765

GSK Investigational Site, Clearwater

33952

GSK Investigational Site, Port Charlotte

34470

GSK Investigational Site, Ocala

34474

GSK Investigational Site, Ocala

43213

GSK Investigational Site, Columbus

43215

GSK Investigational Site, Columbus

45417

GSK Investigational Site, Dayton

48503

GSK Investigational Site, Flint

55125

GSK Investigational Site, Woodbury

55432

GSK Investigational Site, Fridley

60596

GSK Investigational Site, Frankfurt am Main

74136

GSK Investigational Site, Tulsa

77058

GSK Investigational Site, Houston

77375

GSK Investigational Site, Tomball

77429

GSK Investigational Site, Cypress

77521

GSK Investigational Site, Baytown

87108

GSK Investigational Site, Albuquerque

95670

GSK Investigational Site, Gold River

97202

GSK Investigational Site, Portland

377 01

GSK Investigational Site, Jindřichův Hradec

278 01

GSK Investigational Site, Kralupy nad Vltavou

410 02

GSK Investigational Site, Lovosice

337 01

GSK Investigational Site, Rokycany

415 01

GSK Investigational Site, Teplice

4818 CK

GSK Investigational Site, Breda

6419 PC

GSK Investigational Site, Heerlen

7555 DL

GSK Investigational Site, Hengelo

1624 NP

GSK Investigational Site, Hoorn

7207 AE

GSK Investigational Site, Zutphen

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY

NCT03478683 - A Randomized Study, Comparing Fluticasone Furoate/Umeclidinium/Vilanterol (FF/UMEC/VI) Single Inhaler Triple Therapy, Versus Multiple Inhaler Therapy (Budesonide/Formoterol Plus Tiotropium) in Subjects With Chronic Obstructive Pulmonary Disease (COPD) | Biotech Hunter | Biotech Hunter