63
Participants
Start Date
May 25, 2018
Primary Completion Date
May 21, 2020
Study Completion Date
May 21, 2020
1,25 (OH)2 D3
0.25 micrograms, taken daily for eight weeks, orally
Inspiratory isometric resistance training
A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.Participants in the active groups will breathe against a resistance set to generate 30% of maximal inspiratory pressure (PImax).
Oral Placebo
Placebo will be created to mimic the appearance of the study drug
Sham Inspiratory Isometric Resistance Training
A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles. Participants in the sham group will train daily against a resistance set to only 15% PImax.
Threshold Inspiratory Muscle Trainer (IMT)
A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.
Mayo Clinic in Rochester, Rochester
Lead Sponsor
Andersen Foundation
OTHER
Mayo Clinic
OTHER