Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients

PHASE4CompletedINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

May 25, 2018

Primary Completion Date

May 21, 2020

Study Completion Date

May 21, 2020

Conditions
Cancer
Interventions
DRUG

1,25 (OH)2 D3

0.25 micrograms, taken daily for eight weeks, orally

OTHER

Inspiratory isometric resistance training

A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.Participants in the active groups will breathe against a resistance set to generate 30% of maximal inspiratory pressure (PImax).

DRUG

Oral Placebo

Placebo will be created to mimic the appearance of the study drug

OTHER

Sham Inspiratory Isometric Resistance Training

A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles. Participants in the sham group will train daily against a resistance set to only 15% PImax.

DEVICE

Threshold Inspiratory Muscle Trainer (IMT)

A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.

Trial Locations (1)

55905

Mayo Clinic in Rochester, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Andersen Foundation

OTHER

lead

Mayo Clinic

OTHER

NCT03469271 - Maintain Respiratory Muscle Function and Reduce Pneumonia Risk in Cancer Patients | Biotech Hunter | Biotech Hunter