Improving Postamputation Functioning by Decreasing Phantom Pain With Perioperative Continuous Peripheral Nerve Blocks: A Department of Defense Funded Multicenter Study

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

203

Participants

Timeline

Start Date

March 23, 2018

Primary Completion Date

August 18, 2026

Study Completion Date

November 18, 2026

Conditions
Lower Extremity Surgical AmputationPost-amputation Phantom Limb Pain
Interventions
DRUG

Experimental continuous peripheral nerve blocks

Bupivacaine 0.3% \[or ropivacaine 0.5%\] infusions for 7 days via femoral and sciatic perineural catheters

DRUG

Control continuous peripheral nerve blocks

Bupivacaine 0.1% \[or ropivacaine 0.2%\] infusions for 1 day followed by normal saline for a total of 7 days via femoral and sciatic perineural catheters

Trial Locations (8)

44111

Fairview Hospital, Cleveland

44195

Cleveland Clinic, Cleveland

77030

University of Texas MD Anderson Cancer Center, Houston

92103

University California San Diego, San Diego

92134

Naval Medical Center San Diego, San Diego

02114

Mass. General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

02130

Boston VA, Boston

All Listed Sponsors
collaborator

United States Department of Defense

FED

collaborator

United States Naval Medical Center, San Diego

FED

collaborator

The Cleveland Clinic

OTHER

collaborator

Walter Reed National Military Medical Center

FED

collaborator

Johns Hopkins University

OTHER

collaborator

Wake Forest University Health Sciences

OTHER

collaborator

Boston VA

UNKNOWN

collaborator

Massachusetts General Hospital

OTHER

collaborator

Brigham and Women's Hospital

OTHER

lead

University of California, San Diego

OTHER