Cognition Evolution and MRI Markers in PPMS Patients on 2 Years

Expanded Disability Status Scale (EDSS), ambulation test and Multiple Sclerosis functional composite (MSFC). Medications will be recorded.

Virtual reality task and Actual reality

cognitive tests exploring information processing speed, attention/concentration, working and episodic memories and executive function

questionnaires for depression, anxiety and fatigue

morphological MRI and resting state functional MRI (fMRI)