1,205
Participants
Start Date
June 1, 2024
Primary Completion Date
April 27, 2027
Study Completion Date
September 15, 2027
cholinesterase inhibitors (CI) (donepezil, galantamine or rivastigmine)
"The choice of the treatment will be done by the specialist according to his habits; the specialist will monitor the treatment as usual. All the recruited patients will be treated by CI according to the recommendations of the French HAS and the clinician's habits to choose the type of CI and adjust the dosage. After a 6-month period under CI treatment, patients will be classified according to the evolution of the Mini Mental State Examination (MMSE) as non-responders or responders.~Responders patients will continue their treatment according to the habits of the clinician. Non-responder patients will be included in the RCT, with individual randomization in two groups: one group who stops the CI, one group who continues the CI. All randomized patients will then be followed-up for two years with regular assessment of judgment criteria every 6 months."
CHU Côte de Nacre Service de neurologie et CMRR, Caen
CHU de Bastia Centre Mémoire Ressources Recherche, Bastia
CHU de Dijon- CMRR, Dijon
CHU de Besançon Centre Mémoire Ressources Recherche, Besançon
CHRU Cavale Blanche Service de Gériatrie, Brest
CHU de Bordeaux - Service de Neurologie - Centre Mémoire Ressources Recherche -, Bordeaux
CHU Montpellier Hôpital Gui de Chauliac CMRR, Montpellier
CHU de Rennes - Hôpital Pontchaillou / Service de Neurologie, Rennes
CHRU de Bretonneau Unité de gérontopsychiatrie, Tours
Chu de Grenoble CMRR, Neurologie, Grenoble
Chu de Saint-Etienne, CMRR, Saint-Etienne
CHU de Nantes Clinique Neurologique Hôpital GR Laennec, Nantes
CHU d'Angers Centre Mémoire Ressources Recherche, Angers
CHU Reims Hôpital Maison Blanche Court Séjour Gériatrique, Reims
CHU Nancy Service de Gériatrie-CMRR, Vandœuvre-lès-Nancy
Hôpital Roger Salengro CMRR, Lille
CHU de Clermont Ferrand Centre Mémoire Ressources Recherche, Clermont-Ferrand
Chu de Strasbourg Hôpital Ka Robertsau Pôle de Gériatrie - CMRR, Strasbourg
Hôpital Pasteur Service de Neurologie, Colmar
Hospice Civil de Lyon Hôpital des Charpennes, Villeurbanne
Service de Neuropsychologie Hôpital Neurologique Pierre Wertheimer, Bron
APHP Hôpital Broca, Paris
Hôpital Universitaire de la Pitié Salpêtrière Pavillon François Lhermitte, Paris
APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal CMRR, Paris
CHU de Rouen Hôpital Charles Nicolle Service Neurologie, Rouen
CHU d'Amiens Centre Mémoire Ressources Recherche, Amiens
CHU La Milétrie Pôle de Gériatrie, Poitiers
CHU Limoges Service de neurologie et CMRR, Limoges
AP-HM, Marseille
Centre de Recherche Clinique du Gérontopôle Cité de la Santé, Toulouse
Institut Claude Pompidou Centre Mémoire de Ressources et de Recherche, Nice
University Hospital, Bordeaux
OTHER