CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers

PHASE1CompletedINTERVENTIONAL
Enrollment

117

Participants

Timeline

Start Date

April 25, 2018

Primary Completion Date

December 28, 2022

Study Completion Date

February 19, 2023

Conditions
Non-Small Cell Lung CancerRenal Cell CancerColorectal CancerTriple Negative Breast CancerCervical CancerOvarian CancerPancreatic CancerEndometrial CancerSarcomaSquamous Cell Carcinoma of the Head and NeckBladder CancerMetastatic Castration Resistant Prostate CancerNon-hodgkin Lymphoma
Interventions
DRUG

CPI-006

Subjects will receive escalating doses of CPI-006 administered intravenously once every 21 days until MTD is reached or until disease progression.

DRUG

CPI-006 + ciforadenant

Subjects will receive escalating doses of CPI-006 administered intravenously once every 21 days in combination with CPI-444 orally twice daily until MTD is reached for CPI-006 or until disease progression.

DRUG

CPI-006 + pembrolizumab

Subjects will receive escalating doses of CPI-006 in combination with pembrolizumab administered intravenously once every 21 days until MTD is reached for CPI-006 or until disease progression.

DRUG

CPI-006

Selected dose of CPI-006 administered intravenously once every 21 days until disease progression.

DRUG

CPI-006 + ciforadenant

Selected dose of CPI-006 administered intravenously once every 21 days, in combination with CPI-444 orally twice daily until disease progression.

DRUG

CPI-006 + pembrolizumab

Selected dose of CPI-006 in combination with pembrolizumab administered intravenously once every 21 days until disease progression.

Trial Locations (27)

2010

St. Vincent's Hospital, Darlinghurst

2050

Lifehouse, Camperdown

3168

Westmead, Westmead

Monash Hospital, Clayton

4029

Royal Brisbane, Herston

10029

Icahn School of Medicine at Mount Sinai, New York

12206

NY Hematology, Albany

14263

Roswell Park Cancer Institute, Buffalo

15232

UPMC Hillman, Pittsburgh

21224

The John Hopkins University, Baltimore

22031

Virginia Cancer, Fairfax

28078

Carolina BioOncology Institute, Huntsville

29605

Greenville, Greenville

33136

University of Miami, Miami

37203

Sarah Cannon Research Institute, Nashville

45242

Oncology Hematology Care, Cincinnati

53226

Froedtert Hospital & Medical College of Wisconsin, Milwaukee

60611

Northwestern University, Chicago

60637

The University of Chicago, Chicago

73104

University of Oklahoma - Stephenson Cancer Center, Oklahoma City

75230

Mary Crowley Cancer Research, Dallas

85711

Arizona Oncology, Tucson

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

91010

City Of Hope, Duarte

94143

UC San Francisco, San Francisco

06519

Yale School of Medicine, New Haven

02215

Dana Farber, Boston

Sponsors
All Listed Sponsors
lead

Corvus Pharmaceuticals, Inc.

INDUSTRY

NCT03454451 - CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers | Biotech Hunter | Biotech Hunter