An Efficacy and Safety Study of Palovarotene for the Treatment of MO

PHASE2TerminatedINTERVENTIONAL
Enrollment

193

Participants

Timeline

Start Date

March 22, 2018

Primary Completion Date

March 24, 2020

Study Completion Date

October 30, 2020

Conditions
Exostoses, Multiple Hereditary
Interventions
DRUG

Palovarotene 2.5 mg

Subjects received a weight-adjusted dose equivalent of 2.5 mg palovarotene, once daily, for up to 24 months.

DRUG

Palovarotene 5.0 mg

Subjects received a weight-adjusted dose equivalent of 5.0 mg palovarotene, once daily, for up to 24 months.

OTHER

Placebo

Subjects received placebo, once daily, for up to 24 months.

Trial Locations (31)

2145

Westmead Children's Hospital, Westmead

2650

UZ Antwerpen, Edegem

19104

The Children's Hospital of Philadelphia (CHOP), Philadelphia

20010

Children's National Medical Center, Washington D.C.

21205

Johns Hopkins University, Baltimore

28046

Hospital Universitario La Paz, Madrid

31059

Hôpital des Enfants, CHU de Toulouse, Toulouse

34093

Bezmialem Vakif University Medical Faculty Hospital, Istanbul

40136

Istituti Ortopedici Rizzoli, Bologna

55905

Mayo Clinic - PPDS, Rochester

60707

Shriners Hospital for Children - Chicago, Chicago

75015

Hôpital universitaire Necker - Enfants Malades, Paris

77030

Memorial Hermann Hospital, Houston

90027

Children's Orthopaedic Center, Los Angeles

94158

University of California-San Francisco, San Francisco

95817

Shriners Hospital for Children - Sacramento, Sacramento

97239

Shriners Hospitals for Children - Portland, Portland

330407

The Paley Institute, West Palm Beach

4668560

Nagoya University Hospital, Nagoya

02115

Boston Children's Hospital, Boston

19410-4160

Shriners Hospital for Children - Philadelphia, Philadelphia

M5G 1X8

Hospital for Sick Children, Toronto

H3T 1C5

Centre Hospitalier Universitaire Sainte-Justine, Montreal

H4A 0A9

Shriners Hospital for Children - Canada, Montreal

565-0871

Osaka University Hospital, Suita

1091 AC

OLVG locatie Oost, Amsterdam

3000-602

Hospital Pediátrico de Coimbra, Coimbra

Unknown

Ege University Medical Faculty Hospital, Bornova

SE1 7EH

Evelina London Children's Hospital, London

M13 9WL

Royal Manchester Childrens Hospital, Manchester

HA7 4LP

Royal National Orthopaedic Hospital, Stanmore

Sponsors
All Listed Sponsors
lead

Clementia Pharmaceuticals Inc.

INDUSTRY