PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC

PHASE2CompletedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

March 9, 2018

Primary Completion Date

September 21, 2020

Study Completion Date

December 2, 2024

Conditions
Colon Cancer
Interventions
DRUG

Panitumumab

6 mg/kg via IV every 2 weeks in combination with nivolumab and ipilimumab

DRUG

Nivolumab

240 mg via IV every 2 weeks in combination with panitumumab and ipilimumab

DRUG

Ipilimumab

1 mg/kg via IV every 6 weeks in combination with nivolumab and panitumumab

Trial Locations (5)

27509

University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center, Chapel Hill

33612

Moffitt Cancer Center, Tampa

37232

Vanderbilt University Medical Center, Nashville

46202

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

98109

University of Washington - Seattle Cancer Care Alliance, Seattle

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Amgen

INDUSTRY

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

UNC Lineberger Comprehensive Cancer Center

OTHER

NCT03442569 - PhII Trial Panitumumab, Nivolumab, Ipilimumab in Kras/Nras/BRAF Wild-type MSS Refractory mCRC | Biotech Hunter | Biotech Hunter