Repetitive Acute Intermittent Hypoxia for Spinal Cord Repair

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 9, 2020

Primary Completion Date

December 28, 2024

Study Completion Date

December 28, 2025

Conditions
Spinal Cord Injuries
Interventions
OTHER

Repeated exposure to acute Intermittent Hypoxia (rAIH)

Participants will be fitted with a mask that will be placed over mouth and nose. Tubing will be attached to the front of the mask. The session will last approximately 30-45 minutes with 60-90 seconds of lower oxygen (tubing attached, 9-10% oxygen level), alternating with 60-90 sec of normal room air (no tubing attached).

OTHER

Normal Room Air

Participants will be fitted with a mask that will be placed over mouth and nose. Tubing will be attached to the front of the mask. The session will last approximately 30-45 minutes with 60-90 seconds of normal room air (with tubing attached to the mask) and 60-90 sec of normal room air (without the tubing attached to the mask).

OTHER

Upper-limb Training by Research Staff

Training sessions will last for approximately 30 minutes, with additional time for set up. During these sessions, participants will be asked to complete a variety of tasks related to general arm/hand movement, gross grasping, fine grasping, and hand cycle using an arm ergometer. The number of repetitions will be monitored and adjust the difficulty to ensure appropriate task difficulty.

OTHER

Lower-limb Training by Research Staff

Training sessions will last for approximately 30 minutes, with additional time for set up. During these sessions, participants will be asked to complete a variety of tasks related to general leg/foot movement, over-ground walking, treadmill walking, stair climbing training, leg cycling, standing frame, and NuStep. The number of repetitions will be monitored and adjust the difficulty to ensure appropriate task difficulty.

Trial Locations (1)

60611

RECRUITING

Shirley Ryan AbilityLab, Chicago

All Listed Sponsors
collaborator

U.S. Department of Education

FED

lead

Shirley Ryan AbilityLab

OTHER