80
Participants
Start Date
March 23, 2018
Primary Completion Date
December 31, 2025
Study Completion Date
March 31, 2026
Ascorbic Acid
Given IV
Carboplatin
Given IV or PO
Cisplatin
Given IV or PO
Cytarabine
Given IV or PO
Dexamethasone
Given IV or PO
Etoposide
Given IV or PO
Gemcitabine Hydrochloride
Given IV or PO
Ifosfamide
Given IV or PO
Laboratory Biomarker Analysis
Correlative studies
Oxaliplatin
Given IV or PO
Placebo Administration
Given normal saline IV
Questionnaire Administration
Ancillary studies
Rituximab
Given IV
Decitabine
Given IV
Biospecimen Collection
Undergo blood sample collection
Core Biopsy
Undergo core needle biopsy
Bone Marrow Aspiration
Undergo bone marrow aspiration and biopsy
Bone Marrow Biopsy
Undergo bone marrow aspiration and biopsy
Echocardiography
Undergo ECHO
Positron Emission Tomography
Undergo PET/CT
Magnetic Resonance Imaging
Undergo MRI
Central Venous Cannula Insertion
Undergo PICC placement
Portacath Placement
Undergo portacath placement
Computed Tomography
Undergo PET/CT
ACTIVE_NOT_RECRUITING
Mayo Clinic Health System-Franciscan Healthcare, La Crosse
NOT_YET_RECRUITING
Mayo Clinic Health System-Eau Claire Clinic, Eau Claire
RECRUITING
Mayo Clinic in Rochester, Rochester
NOT_YET_RECRUITING
Mayo Clinic Health Systems-Mankato, Mankato
Lead Sponsor
National Cancer Institute (NCI)
NIH
Mayo Clinic
OTHER