The AVIATOR Study: Trastuzumab and Vinorelbine With Avelumab OR Avelumab & Utomilumab in Advanced HER2+ Breast Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

June 21, 2018

Primary Completion Date

May 1, 2023

Study Completion Date

May 31, 2026

Conditions
Breast Cancer
Interventions
DRUG

Vinorelbine

work by interfering with cell division, which leaves the tumor unable to grow and spread

DRUG

Trastuzumab

trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2.

DRUG

Avelumab

monoclonal antibody directed against the human immunosuppressive ligand programmed death-ligand 1 (PD-L1) protein

DRUG

Utomilumab

Utomilumab is an antibody designed to stimulate the body's immune system to fight cancer cells

Trial Locations (17)

10065

Memorial Sloan-Kettering Cancer Center, New York

10467

Montefiore Medical Center, The Bronx

19104

University of Pennsylvania, Philadelphia

20007

Georgetown University Medical Center, Washington D.C.

21287

Johns Hopkins University, Baltimore

27710

Duke University Medical Center, Durham

35249

University of Alabama at Birmingham, Birmingham

37232

Vanderbilt University Medical Center, Nashville

46202

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

60637

University of Chicago Medical Center, Chicago

77030

Baylor College of Medicine, Houston

MD Anderson Cancer Center, Houston

94158

University of California San Francisco, San Francisco

98109

University of Washington Fred Hutchinson Cancer Care, Seattle

02115

Beth Israel Deaconess Medical Center, Boston

02215

Dana-Farber Cancer Institute, Boston

27599-7305

University of Carolina at Chapel Hill, Chapel Hill

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

collaborator

Breast Cancer Research Foundation

OTHER

collaborator

Johns Hopkins University

OTHER

lead

Adrienne G. Waks

OTHER