Cisplatin + Radiotherapy vs Durvalumab + Radiotherapy Followed by Durvalumab vs Durvalumab + Radiotherapy Followed by Tremelimumab + Durvalumab in Intermediate-Risk HPV-Positive Oropharyngeal SCC

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

May 28, 2018

Primary Completion Date

January 31, 2026

Study Completion Date

July 31, 2026

Conditions
Oropharyngeal Squamous Cell Carcinoma
Interventions
RADIATION

Radiation

70 Gy in 35 fractions over 7 weeks (i.e. 2 Gy per fraction)

DRUG

Cisplatin

100 mg/m2 days 1, 22, 43 concurrently with RT

DRUG

Durvalumab

Given in concurrent and adjuvant phase

DRUG

Tremelimumab

ARM CLOSED TO ACCRUAL - 2019

Trial Locations (26)

1200

Cliniques Universitaires Saint-Luc, Brussels

5000

Clinique St. Elizabeth, Namur

9000

University Hospital of Gent, Ghent

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

28034

University Hospital Ramon y Cajal, Madrid

31008

Complejo Hospitalario de Navarra, Pamplona

46010

University Clinical Hospital of Valencia, Valencia

Unknown

University Hospital of Antwerp, Edegem

B-3000

University Hospital Leuven, Leuven

B-2610

AZ Sint Augustinus, Wilrijk

T6G 1Z2

Cross Cancer Institute, Edmonton

R3E 0V9

CancerCare Manitoba, Winnipeg

B3H 1V7

QEII Health Sciences Centre, Halifax

P3E 5J1

Health Sciences North, Greater Sudbury

L8V 5C2

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

K7L 2V7

Kingston Health Sciences Centre, Kingston

N6A 5W9

London Regional Cancer Program, London

K1H 8L6

Ottawa Hospital Research Institute, Ottawa

M5G 2M9

University Health Network, Toronto

H3T 1E2

The Jewish General Hospital, Montreal

H4A 3J1

The Research Institute of the McGill University, Montreal

J1H 5N4

CIUSSS de l'Estrie - Centre hospitalier, Sherbrooke

S4T 7T1

Allan Blair Cancer Centre, Regina

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

08035

University Hospital Vall dHebron, Barcelona

08907

Hospital Duran i Reynals, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Canadian Cancer Trials Group

NETWORK