NCT03396718View on ClinicalTrials.gov

De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas

NARecruitingINTERVENTIONAL
Enrollment

304

Participants

Timeline

Start Date

November 29, 2018

Primary Completion Date

November 30, 2029

Study Completion Date

November 30, 2032

Conditions
Head-and-neck Squamous Cell Carcinoma
Interventions
RADIATION

De-escalation radio(chemo)therapy - Level 1

55/ 59,4 Gy (intermediate / high risk group)

RADIATION

De-escalation radio(chemo)therapy - Level 2

48,4/ 55 Gy (intermediate / high risk group)

RADIATION

Standard radio(chemotherapy)

60/ 66 Gy (intermediate / high risk group)

Trial Locations (10)

13353

NOT_YET_RECRUITING

Charité - Universitätsmedizin Berlin, Berlin

45147

RECRUITING

University Clinic Essen, Essen

60590

RECRUITING

University Clinic Frankfurt, Frankfurt am Main

69120

RECRUITING

University Clinic Heidelberg, Heidelberg

72016

RECRUITING

University Clinic Tübingen, Tübingen

79106

RECRUITING

University Clinic Freiburg, Freiburg im Breisgau

81377

RECRUITING

LMU Munich University Hospital, München

81675

RECRUITING

TUM University Hospital, München

93053

RECRUITING

University Clinic Regensburg, Regensburg

01307

RECRUITING

University Clinic Dresden, Dresden

All Listed Sponsors
collaborator

German Cancer Research Center

OTHER

collaborator

National Center for Tumor Diseases (NCT) Dresden

UNKNOWN

collaborator

National Center for Tumor Diseases, Heidelberg

OTHER

collaborator

Radiation Oncology Working Group of the German Cancer Society

OTHER

lead

Technische Universität Dresden

OTHER