Los Tres Paso: Neoadjuvant Palbociclib Monotherapy, Concurrent Chemoradiation Therapy, Adjuvant Palbociclib Monotherapy in Patients With p16INK4a Negative, HPV-Unrelated Head and Neck Squamous Cell Carcinoma

Palbociclib is an oral drug available as capsules (or as liquid suspension). The capsules should be taken with food

-Cetuximab must not be administered as an IV push or bolus

-Patients will receive cisplatin via intravenous (IV) infusion over 60 minutes.

-Once daily fractions Monday through Friday, with one additional fraction of RT administered on (preferably) Fridays

"* Tumor tissue will be collected at baseline and then after two cycles of neoadjuvant palbociclib monotherapy~* If the patient has been previously enrolled in Washington University's TAP protocol (head and neck bank, HRPO #201102323), tissue that has been banked may be accessed in lieu of fresh biopsy at baseline."

Baseline and post-treatment