Neo-Adjuvant Bladder Urothelial Carcinoma COmbination-immunotherapy

PHASE1CompletedINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

January 15, 2018

Primary Completion Date

July 19, 2021

Study Completion Date

January 7, 2025

Conditions
Urothelial Carcinoma
Interventions
DRUG

Ipilimumab

"For Cohort 1:~* Day 1: Ipilimumab 3 mg/kg~* Days 22: Ipilimumab 3 mg/kg~For Cohort 2a:~* Day 1: Ipilimumab 3 mg/kg~* Days 22: Ipilimumab 3 mg/kg~For Cohort 2b:~* Day 1: Ipilimumab 1 mg/kg~* Days 22: Ipilimumab 1 mg/kg"

DRUG

Nivolumab

"For Cohort 1:~* Day 22: Nivolumab 1 mg/kg~* Day 43: Nivolumab 3 mg/kg~For Cohort 2a:~* Days 1 and 22: Nivolumab 1 mg/kg~* Day 43: Nivolumab 3 mg/kg~For Cohort 2b:~\- Days 1, 22 and 43: Nivolumab 3 mg/kg"

Trial Locations (3)

1066CX

Antoni van Leeuwenhoek ziekenhuis, Amsterdam

Unknown

Radboud UMC, Nijmegen

UMC Utrecht, Utrecht

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

The Netherlands Cancer Institute

OTHER