178
Participants
Start Date
March 12, 2018
Primary Completion Date
December 31, 2021
Study Completion Date
December 31, 2021
Unfractionated heparin
UFH initiated at 18 IU/kg/hr, dosed according to total body weight and pragmatically adjusted according to local institutional policy to achieve an activated partial thromboplastin (aPTT) of 1.5 to 2.5 times that of the reference aPTT value or anti-Xa values targeted to local practice levels. Duration of study intervention will be a maximum of 5 days (120 hours) or until vasopressors have been discontinued for 24 continuous hours. All participants will then receive venous thromboprophylaxis according to local practice.
Venous thromboprophylaxis (VTE)
May include subcutaneous heparin or dalteparin, sequential compression device or graduated compression stockings
Froedtert Hospital, Milwaukee
Hospital Sao Jose, Altamira
Hospital Novo Atibaia, Atibaia
Hospital de Amor (Barretos), Barretos
Santa Casa de Misericórdia de Belo Horizonte, Belo Horizonte
Hospital Tacchini, Bento Gonçalves
Hospital de Brasília, Brasília
Hospital Ortopedico e Medicina Especializada ltda. - HOME, Brasília
Instituto de Cardiologia do Distrito Federal, Brasília
Hospital Maternidade São José, Colatina
Hospital Baía Sul, Florianópolis
Hospital Nereu Ramos, Florianópolis
Hospital de Amor Jales, Jales
Unimed Cariri Hospital, Juazeiro do Norte
Hospital de Clínicas de Porto Alegre, Porto Alegre
Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre
Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto, Ribeirão Preto
Hospital Bruno Born, Rio Grande
Hospital da Cidade, Salvador
Santa Casa de São João Del Rei, São João del Rei
Hospital AC Camargo, São Paulo
Hospital Beneficência Portuguesa, São Paulo
Hospital da Luz, São Paulo
Hospital das Clinicas da faculdade de Medicina de Universidade de São Paulo, São Paulo
Hospital e Maternidade Sao Vicente, São Paulo
Hospital Santa Paula, São Paulo
Hospital Sepaco, São Paulo
Instituto de Assistência Médica ao Servidor Público Estadual de São Paulo, São Paulo
Universidade Federal de Sao Paulo - UNIFESP, São Paulo
Hospital Ana Nery, Taguatinga
ATTIKON University Hospital, Athens
Korgialeneion Benakeion Hospital, Athens
AMRI Hospital Kolkata, Kolkata
Dr Ruth K.M. PFAU Civil Hospital, Karachi
Shaheed Mohtarma Benazir Bhutto Trauma Center, Karachi
The Indus Hospital, Karachi
Mayo Hospital Lahore, Lahore
The Asian Hospital, Manila
The Medical City, Manila
The Philippines General Hospital, Manila
Foothills Medical Centre, Calgary
Vancouver Island Health Authority, Victoria
St Boniface General Hospital, Winnipeg
Health Sciences Centre Winnipeg, Winnipeg
The Ottawa Hospital - General Campus, Ottawa
The Ottawa Hospital - Civic Campus, Ottawa
Niagara Health System - St Catharines Site, Saint Catherines
St Michael's Hospital, Toronto
Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal
Institut Universitaire de Cardiologie et de Pneumologie de Quebec - Universite Laval, Québec
Hopital de l'Enfant-Jesus, Québec
Collaborators (1)
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
CancerCare Manitoba
OTHER
University of Manitoba
OTHER