An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Cancer of the Colon or Rectum That Has Spread

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

325

Participants

Timeline

Start Date

January 31, 2018

Primary Completion Date

November 4, 2024

Study Completion Date

November 4, 2024

Conditions
Colorectal CancerColorectal TumorsColorectal CarcinomaColorectal Neoplasm
Interventions
BIOLOGICAL

Nivolumab

Specified dose on specified days

DRUG

Trametinib

Specified dose on specified days

BIOLOGICAL

Ipilimumab

Specified dose on specified days

DRUG

Regorafenib

Specified dose on specified days

Trial Locations (47)

0

Local Institution - 0055, Clayton

1181

Local Institution - 0123, Buenos Aires

1200

Local Institution, Woluwe-Saint-Lambert

1431

Local Institution - 0119, Buenos Aires

2148

Local Institution - 0044, Blacktown

3084

Local Institution - 0069, Heidelberg

4215

Local Institution - 0043, Southport

10016

Local Institution - 0104, New York

17604

Local Institution - 0100, Lancaster

19104

Local Institution - 0003, Philadelphia

19107

Thomas Jefferson University - Clinical Research Institute, Philadelphia

20089

Local Institution - 0094, Rozzano

20133

Local Institution - 0093, Milan

21287

Local Institution - 0028, Baltimore

28007

Local Institution - 0114, Madrid

28041

Local Institution - 0051, Madrid

28050

Local Institution - 0115, Madrid

28204

Local Institution - 0029, Charlotte

30625

Local Institution - 0004, Hanover

31009

Local Institution - 0080, Pamplona

32610

Local Institution - 0107, Gainesville

33136

Local Institution - 0111, Miami

35128

Local Institution - 0092, Padua

35249

Local Institution - 0022, Birmingham

41013

Local Institution - 0096, Seville

63110

Local Institution - 0103, St Louis

65653

Local Institution - 0071, Brno

76508

Local Institution - 0101, Temple

90033

Local Institution - 0027, Los Angeles

90089

Local Institution - 0067, Los Angeles

94158

Local Institution - 0001, San Francisco

95124

Local Institution - 0095, Catania

8420383

Local Institution - 0118, Santiago

39401-7233

Local Institution - 0116, Hattiesburg

53792-0001

Local Institution - 0002, Madison

C1426ANZ

Local Institution - 0120, Ciudad Autónoma de Buenos Aires

C1096AAS

Local Institution - 0122, Buenos Aires

05112

Local Institution - 0068, Elizabeth Vale

T6G 1Z2

Local Institution - 0113, Edmonton

M5G 2M9

Local Institution - 0070, Toronto

H2X 0A9

Local Institution - 0077, Montreal

K1H 8L6

Local Institution - 0076, Ottawa

000000

Local Institution - 0117, Santiago

779 00

Local Institution - 0072, Olomouc

500 05

Local Institution - 0073, Hradec Králové

08916

Local Institution - 0079, Badalona

08035

Local Institution - 0052, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY

NCT03377361 - An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab In Participants With Previously Treated Cancer of the Colon or Rectum That Has Spread | Biotech Hunter | Biotech Hunter