Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

September 6, 2019

Primary Completion Date

November 1, 2026

Study Completion Date

December 30, 2026

Conditions
Metastatic Breast CancerHER2 Positive Breast Carcinoma
Interventions
DRUG

Niraparib

Niraparib is an oral PARP-1 and -2 inhibitor with high potency.

DRUG

Trastuzumab

Trastuzumab is a commercially available agent administered by intravenous infusion. A loading dose of 8 mg/kg will be given as the first dose followed with all subsequent doses of 6 mg/kg every 3 weeks.

Trial Locations (7)

10461

Montefiore, The Bronx

19104

University of Pennsylvania, Philadelphia

27599

University of North Carolina, Chapel Hill

35294

University of Alabama at Birmingham, Birmingham

55905

Mayo Clinic, Rochester

60637

University of Chicago, Chicago

98109

University of Washington-, Seattle

All Listed Sponsors
collaborator

Translational Breast Cancer Research Consortium

OTHER

collaborator

Tesaro, Inc.

INDUSTRY

collaborator

Susan G. Komen Breast Cancer Foundation

OTHER

collaborator

Breast Cancer Research Foundation of Alabama

UNKNOWN

collaborator

The V Foundation

OTHER

lead

University of Alabama at Birmingham

OTHER

NCT03368729 - Niraparib in Combination With Trastuzumab in Metastatic HER2+ Breast Cancer | Biotech Hunter | Biotech Hunter