Loose-dose Combination of Acarbose and Metformin for T2DM in Metformin-failure Patients

PHASE3CompletedINTERVENTIONAL
Enrollment

287

Participants

Timeline

Start Date

March 5, 2018

Primary Completion Date

August 12, 2019

Study Completion Date

August 21, 2019

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

Acarbose

Uptitrated in the treatment phase from 50 mg per day for 1 week, followed by 100 mg per day for another week, and 150 mg per day for the rest 14 weeks, oral, with the first mouthful of main meal

DRUG

Metformin

500 mg 3 times daily, oral, with the first mouthful of main meal

DRUG

Placebo

Acarbose matching placebo, oral

Trial Locations (29)

100028

Emergency General Hospital, Beijing

100730

Peking Union Medical College Hospital CAMS, Beijing

101200

Beijing Pinggu Hospital, Beijing

130021

Jilin Province People's Hospital, Changchun

200072

Shanghai Tenth People's Hospital, Shanghai

210029

Jiangsu Province Hospital, Nanjing

213003

1st Peopl's Hosp of Changzhou 3rd Affil Hosp of Soochow Univ, Changzhou

223300

Huai'an First People's Hospital, Nanjing Medical University, Huai'an

225001

Northern Jiangsu People's Hospital, Yangzhou

230001

Anhui Provincial Hospital, Hefei

230022

The First Affiliated Hospital of Anhui Medical University, Hefei

250021

Shandong Provincial Hospital, Jinan

272000

Affiliated Hospital of Jining Medical University, Jining

300121

Tianjin Union Medicine Centre (People's Hospital of Tianjin), Tianjin

337055

Jiangxi PingXiang people's Hospital, Pingxiang

410004

Changsha Central Hospital, Changsha

423000

Chenzhou No. 1 People's Hospital, Chenzhou

430030

Tongji Hosp. of Tongji Med Coll, Huazhong Uni of Sci & Tech., Wuhan

442008

Taihe Hospital, Shiyan

450052

The first affiliated hospital of Zhengzhou University, Zhengzhou

471000

1st Affiliated Hospital of Henan Science and Technology Univ, Luoyang

510080

The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou

510120

Sun Yat-Sen Memorial Hosp. Sun Yat-Sen Univ., Guangzhou

510150

The 3rd Affiliated Hospital of Guangzhou Medical University, Guangzhou

570311

The Second Affliated Hospital of Hainan Medical University, Haikou

572000

Hainan Third People's Hospital (Province Nongken Sanya Hopt), Sanya

610041

West China Hospital, Sichuan University, Chengdu

710061

1st Affiliated Hospital of Xi'an Jiaotong Medical University, Xi'an

830001

People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY

NCT03349684 - Loose-dose Combination of Acarbose and Metformin for T2DM in Metformin-failure Patients | Biotech Hunter | Biotech Hunter